Products for Research Use Only
RegisterLogin

Tamapin

CAT: 0466-10TAM001-01000Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0466-10TAM001-01000Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tamapin is a peptide toxin isolated from the venom of the Indian red scorpion Mesobuthus Tamulus. Tamapin is amidated at its C-terminal tyrosine residue. Tamapin binds to small conductance Ca2+-activated K+ channels (SK channels) with high affinity and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus as well as in cell lines expressing distinct SK channel subunits. Contrary to Apamin or Leiurotoxin-1 (Scyllatoxin), Tamapin is an excellent toxin to discriminate among SK channel subtypes because it presents different affinities for SK1 (42 nM), SK2 (24 pM) and SK3 (1.7 nM) channels. This toxin is also the most potent SK2 channel blocker characterized so far (IC50 for SK2 channels = 24 pM) .
Specifications
Selective blocker of SK2 (KCa2.2) channels
Target
K channels
Sequence
AFCNLRRCELSCRSLGLLGKCIGEECKCVPY
Peptide Number
10TAM001
Disulfide Bonds
Cys3-Cys21; Cys8-Cys26; Cys12-Cys28
N Terminal Sequence
H
C Terminal Sequence
NH2

Alternative Products

CatalogName
PP51200Tamapin
MBS5821830Tamapin TFA
HY-P5154A-01Tamapin (TFA)

Popular Products