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OD1

CAT: 0466-ODX001-00500Size: 0.5 mgDry Ice: NoHazardous: No
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CAT#:0466-ODX001-00500Size:0.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OD1 is a scorpion peptide that has been isolated initially from the venom of the scorpion Odonthobuthus doriae. OD1 potently inhibits fast inactivation of mammalian channels Nav1.7 (EC50 4.5 nM), Nav1.4 (EC50 10 ± 2 nM) and Nav1.6 (EC50 47 ± 10 nM) . OD1 also blocks fast inactivation of the para/tipE insect channel (EC50 80 nM) . OD1 weakly affects mammalian Nav1.3 and Nav1.5 (EC50 > 1 μM) and does not affect Nav1.2 and Nav1.8. OD1 induces spontaneous pain when injected in animal in association with our without Veratridine and can be used to test the analgesic effects of Nav1.7 blockers in-vivo.
Specifications
Nav1.7 channel activator
Target
Na channels
Sequence
GVRDAYIADDKNCVYTCASNGYCNTECTKNGAESGYCQWIGRYGNACWCIKLPDEVPIRIPGKCR
Peptide Number
ODX001
Disulfide Bonds
Cys13-Cys64; Cys17-Cys37; Cys23-Cys47; Cys27-Cys49
N Terminal Sequence
H
C Terminal Sequence
NH2

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