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ω-Tbo-IT1

CAT: 0466-ITO001-00500Size: 0.5 mgDry Ice: NoHazardous: No
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CAT#:0466-ITO001-00500Size:0.5 mg
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Description
ω-Tbo-IT1 has been isolated from the venom of the Tibellus oblongus spider. ω-Tbo-IT1 is a selective blocker of insects calcium channels. It has been shown that ω-Tbo-IT1 has a potent insect toxicity with LD50 19 μg/g on house fly Musca domestica larvae and LD50 20 μg/g on juvenile Gromphadorhina portentosa cockroaches. Electrophysiological experiments revealed a reversible inhibition of evoked excitatory postsynaptic currents in blow fly Calliphora vicina neuromuscular junctions with an IC50 value 40 ± 10 nM.
Specifications
Selective blocker of insects calcium channels
Target
Ca channels
Sequence
CASKNERCGNALYGTKGPGCCNGKCICRTVPRKGVNSCRCM
Peptide Number
ITO001
Disulfide Bonds
Cys1-Cys21; Cys8-Cys25; Cys20-Cys40
N Terminal Sequence
H
C Terminal Sequence
OH

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