ω-Conotoxin-MVIIC

• Description :

  ω-conotoxin MVIIC (omega conotoxin MVIIC) is a conotoxin that has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC is a blocker of P/Q (IC50=35 nM) and N-type calcium channels. It inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of ω-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. ω-conotoxin MVIIC also presents an inhibition of ω-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats.

• CAS Number :

  147794-23-8

• Specifications :

  Blocker of P/Q and N-type Ca2+ channels

• Target :

  Ca channels

• Sequence :

  CKGKGAPCRKTMYDCCSGSCGRRGKC

• Peptide Number :

  08CON002

• Disulfide Bonds :

  Cys1-Cys16; Cys8-Cys20; Cys15-Cys26

• N Terminal Sequence :

  H

• C Terminal Sequence :

  NH2