TAMRA-ShK

CAT: 0466-SAT001-00100Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0466-SAT001-00100Size:0.1 mg
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Description
TMR-ShK is a fluorescent (red) derivative of the well-known ShK toxin (Stichodactyla helianthus neurotoxin) isolated from the venom of the Carribean sea anemone Stoichactis helianthus. Wild-type ShK blocks potently Kv1.3 (KCNA3), Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) with a Kd value of 11 pM, 16 pM, 312 pM and 165 pM, respectively. The fluorescent TMR-labeled ShK blocks Kv1.3 and Kv1.1 with Kd values of 52 pM and 397 pM, respectively. TMR-ShK can be used to identify lymphocytes expressing Kv1.3 channels such as effective memory T cells (TEM) in the case of autoimmune diseases (type 1 diabetes, mellitus or rheumatoid arthritis) which overexpress Kv1.3 channels.
Specifications
Selective blocker of Kv1.4
Target
K channels
Sequence
RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
Peptide Number
SAT001
Disulfide Bonds
Cys3-Cys35; Cys12-Cys28; Cys17-Cys32
N Terminal Sequence
H
C Terminal Sequence
OH

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