Maurocalcine

CAT: 0466-07MAU001-00100Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0466-07MAU001-00100Size:0.1 mg
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Description
Maurocalcine, a component of the venom of Scorpio maurus palmatus, was discovered by Michel De Waard, co-founder of Smartox. Maurocalcine folds according to an inhibitor cysteine knot. Such as Imperatoxin A, Maurocalcine acts as a high affinity agonist of the type-1 ryanodine receptor expressed in skeletal muscles with an affinity in the 10 nM range. Maurocalcine induces an increase in channel opening probability accompanied by sudden transitions to long lasting subconductance states. Maurocalcine has also been characterized as a cell penetrating peptide and its pharmacological activity can be observed upon extracellular perfusion.
Specifications
Ryanodine receptors agonist
Target
Ca channels
Sequence
GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR
Peptide Number
07MAU001
Disulfide Bonds
Cys3-Cys17; Cys10-Cys21; Cys16-Cys32
N Terminal Sequence
H
C Terminal Sequence
OH

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