Apamin

CAT: 0466-08APA001-00500Size: 0.5 mgDry Ice: NoHazardous: No

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CAT#:0466-08APA001-00500Size:0.5 mg

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Description

Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord. Apamin inhibits three subtypes of SK channels (KCa2.1, KCa2.2, and KCa2.3) with different affinity. Apamin does not affect KCa3.1 channel activity. Apamin most likely acts as a pore blocker such as Scyllatoxin or Tamapin, although residues both inside and outside of the pore region of the SK channels participate in apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.

CAS Number

24345-16-2

Specifications

SK channel blocker

Target

K channels

Sequence

CNCKAPETALCARRCQQH

Peptide Number

08APA001

Disulfide Bonds

Cys1-Cys11; Cys3-Cys15

N Terminal Sequence

C Terminal Sequence

NH2

Alternative Products

Catalog	Name
B6817-.5	Apamin

Apamin

Alternative Products

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