TRAP-6

CAT: 0466-SB032-1MGSize: 1 mgDry Ice: NoHazardous: No
CAT#:0466-SB032-1MGSize:1 mg
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Description
Thrombin Receptor Activator Peptide 6 (TRAP-6), also called Selective Protease-Activated Receptor 1 (PAR-1) Agonist, is an hexapeptide fragment of the thrombin receptor (residues 42-47) . TRAP-6 has been shown to selectively activate PAR1 and thus induce platelet aggregation (EC50 = 0.8 μM) . Its usefulness has therefore been demonstrated in cardiovascular study models and in hematology. Biologically, TRAP-6 is the N-terminal fragment of the thrombin receptor resulting from its cleavage by thrombin. This peptide therefore offers a cost-effective solution for the study of in-vitro cardiovascular models. What is PAR-1 ? Proteinase-activated receptor 1 (PAR1), also known as coagulation factor II (thrombin) receptor, is a G protein-coupled receptor and is involved in the regulation of thrombotic response. It is highly expressed in platelets and endothelial cells Other Applications ? Therefore, this peptide was used to activate platelets in vitro but it also demonstrated a protective action on astrocytes, which is associated with hypoglycemia. Thus, some research has focused on the use of TRAP-6 peptide to study the pathways that regulate hypoglycemia. Others have also been interested in TRAP-6 because of its stimulating action on certain transcription regulators, notably the yes-associated protein (YAP) .
CAS Number
141136-83-6
Product Name Alternative
TRAP 6, Thrombin Receptor Activator Peptide 6, PAR1 agonist, Thrombin Receptor (1-6), Coagulation Factor II Receptor (1-6)
Sequence
SFLLRN
Peptide Number
SB032

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