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Nefopam

CAT: 0804-HY-133195Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-133195Size:1 Each
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Description
Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC50=27 μM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups[1][2][3].
CAS Number
13669-70-0
Product Name Alternative
Fenazoxine
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nefopam.html
Solubility
10 mM in DMSO
Smiles
CN1CCOC(C2=CC=CC=C2)C3=CC=CC=C3C1
Molecular Formula
C17H19NO
Molecular Weight
253.34
References & Citations
[1]Lee JY, et al. The Antiallodynic Effect of Nefopam on Vincristine-Induced Neuropathy in Mice. J Pain Res. 2020 Feb 7;13:323-329. |[2]Kim KH, et al. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr;27 (2) :103-11. |[3]Verleye M, et al. Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res. 2004 Jul 9;1013 (2) :249-55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

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