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Inclisiran

CAT: 0804-HY-132591-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132591-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Inclisiran is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran inhibits the transcription of PCSK9. Inclisiran inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran can be used in researches of hyperlipidemia and cardiovascular disease (CVD) [1][2][3].
CAS Number
1639324-58-5
Product Name Alternative
ALN-PCSsc
UNSPSC
12352208
Hazard Statement
H302, H315, H319, H335
Target
Caspase; Interleukin Related; NOD-like Receptor (NLR) ; PCSK9; PPAR; Pyroptosis; Small Interfering RNA (siRNA)
Type
Oligonucleotides
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/inclisiran.html
Purity
99.71
Solubility
H2O : 5 mg/mL (ultrasonic)
Smiles
[Inclisiran]
Molecular Formula
C529H707F12N176O316P43S6
Molecular Weight
16339.00
Precautions
H302, H315, H319, H335
References & Citations
[1]Constantine E Kosmas, et al. Inclisiran for the Treatment of Cardiovascular Disease: A Short Review on the Emerging Data and Therapeutic Potential. Ther Clin Risk Manag. 2020 Oct 28;16:1031-1037.|[2]Kong N, Xu Q, Cui W, Feng X, Gao H. PCSK9 inhibitor inclisiran for treating atherosclerosis via regulation of endothelial cell pyroptosis. Ann Transl Med. 2022;10 (22) :1205.|[3]Wang Z, et al. Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway. Autoimmunity. 2022 Jun;55 (4) :223-232.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Oligonucleotides
Clinical Information
Launched
Isoform
Caspase 1; IL-1; NLRP3; PPARγ
Citation 01
Biochem Pharmacol. 2025 Jul 27;242 (Pt 2) :117192.|Drug Metab Dispos. 2025 Jun;53 (6) :100089.|J Med Chem. 2025 Apr 24;68 (8) :8190-8207.|medRxiv. 2025 Feb 12.|Ann Transl Med. 2022 Nov;10 (22) :1205.|Biol Methods Protoc. 2024 May 6.

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