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Activated DPG Subunit

CAT: 0804-HY-153405-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153405-02Size:10 mg
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Description
Activated DPG Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy[1].
CAS Number
1155309-89-9
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Oligonucleotides
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/activated-dpg-subunit.html
Purity
95.0
Solubility
DMSO : 5.71 mg/mL (ultrasonic)
Smiles
O=P(Cl)(N(C)C)OC[C@H](CN(C(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C4)O[C@H]4N5C=NC6=C5N=C(NC(CC7=CC=CC=C7)=O)N=C6OCC(C=C8)=CC=C8OC(C(C)(C)C)=O
Molecular Formula
C51H53ClN7O7P
Molecular Weight
942.44
References & Citations
[1]Passini MA, et al. Exon skipping oligomer conjugates for muscular dystrophy. World Intellectual Property Organization, WO2018118599 A1. 2018-06-28.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

Chemical Information

Activated DPG Subunit
CAS Number1155309-89-9
PubChem CID132184621
IUPAC Name[4-[[9-[6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-2-[(2-phenylacetyl)amino]purin-6-yl]oxymethyl]phenyl] 2,2-dimethylpropanoate
Molecular FormulaC51H53ClN7O7P
Molecular Weight942.4
XLogP8.8
Topological Polar Surface Area150
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count18
Heavy Atom Count67
Formal Charge0
Complexity1580
SMILES
CC(C)(C)C(=O)OC1=CC=C(C=C1)COC2=NC(=NC3=C2N=CN3C4CN(CC(O4)COP(=O)(N(C)C)Cl)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)NC(=O)CC8=CC=CC=C8
InChI
InChI=1S/C51H53ClN7O7P/c1-50(2,3)48(61)66-41-28-26-37(27-29-41)33-63-47-45-46(55-49(56-47)54-43(60)30-36-18-10-6-11-19-36)59(35-53-45)44-32-58(31-42(65-44)34-64-67(52,62)57(4)5)51(38-20-12-7-13-21-38,39-22-14-8-15-23-39)40-24-16-9-17-25-40/h6-29,35,42,44H,30-34H2,1-5H3,(H,54,55,56,60)
InChIKey
TXKNJPOHRYJGGF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Activated DPG Subunit
CAS: 1155309-89-9
CID: 132184621
Formula: C51H53ClN7O7P
MW: 942.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight942.4
XLogP38.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count18
Exact Mass941.3432617
Monoisotopic Mass941.3432617
Topological Polar Surface Area150 Ų
Heavy Atom Count67
Formal Charge0
Complexity1580
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count3
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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