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Ertugliflozin

CAT: 0804-HY-15461-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15461-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. Has the potential for the treatment of type 2 diabetes mellitus[2].
CAS Number
1210344-57-2
Product Name Alternative
PF-04971729
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/PF-04971729.html
Purity
99.92
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
ClC1=CC=C([C@]23O[C@@](CO)(CO3)[C@@H](O)[C@H](O)[C@H]2O)C=C1CC4=CC=C(OCC)C=C4
Molecular Formula
C22H25ClO7
Molecular Weight
436.88
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Mascitti V, et al. Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem. 2011 Apr 28;54 (8) :2952-60.|[2]Miao Z, et al. Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos. 2013 Feb;41 (2) :445-56.|[3]Kalgutkar AS, et al. Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. Drug Metab Dispos. 2011 Sep;39 (9) :1609-19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
SGLT2

Alternative Products

CatalogName
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AR-E11054-01Ent-Ertugliflozin
AR-E01787-01Ertugliflozin isomer
CS-O-32494Ertugliflozin-d5
CS-O-32489Mono acetyl Ertugliflozin
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RM-E900021-01Ertugliflozin Impurity 21
RM-E900020-01Ertugliflozin Impurity 20

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