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Sirexatamab

CAT: 0804-HY-P99906-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99906-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sirexatamab (DKN-01) is a humanized IgG4 monoclonal antibody that can bind to and neutralize circulating DKK1. Sirexatamab exhibits antitumor activity in tumor models expressing DKK1[1].
CAS Number
2414962-49-3
Product Name Alternative
DKN-01; LY-2812176
UNSPSC
12352203
Target
β-catenin
Type
Inhibitory Antibodies
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirexatamab.html
Purity
99.84
Solubility
10 mM in DMSO
Smiles
[Sirexatamab]
Molecular Weight
(144 kDa)
References & Citations
[1]Klempner SJ, et al. Safety, Efficacy, and Biomarker Results from a Phase Ib Study of the Anti-DKK1 Antibody DKN-01 in Combination with Pembrolizumab in Advanced Esophagogastric Cancers. Mol Cancer Ther. 2021 Nov;20 (11) :2240-2249.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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