(S,R,S)-AHPC-propargyl

(S,R,S)-AHPC-propargyl

• Product Name Alternative: VH032-propargyl; VHL ligand 7
• CAS Number: 2098799-78-9
• UNSPSC Description: (S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs[1]. (S,R,S)-AHPC-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: Ligands for E3 Ligase
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/s-r-s-ahpc-propargyl.html
• Purity: 99.48
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(COCC#C)=O)C(C)(C)C)=O)=O)C=C2
• Molecular Weight: 526.65
• References & Citations: [1]Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported