Aceglutamide

• Description :

  Aceglutamide (α-N-Acetyl-L-glutamine; N2-Acetylglutamine) is a neuroprotectant that can penetrate the blood-brain barrier. Aceglutamide can enhance the antioxidant systems of glutathione (GSH), thioredoxin (Trx) and Nrf2. Aceglutamide also inhibits ASK1 and TRAF1, activates the Akt/Bcl-2 anti-apoptotic pathway, enhances the activity of antioxidant enzymes and reduces oxidative damage. Aceglutamide can improve neurological deficits after cerebral ischemia, reduce infarct volume, and inhibit neuronal apoptosis, especially substantia nigra dopaminergic neurons. Aceglutamide can reduce cerebral ischemia/reperfusion injury, improve motor dysfunction, and is used in ischemic stroke-related research[1][2].

• Product Name Alternative :

  α-N-Acetyl-L-glutamine; N2-Acetylglutamine

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Akt; Apoptosis; ASK1; Keap1-Nrf2

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; NF-κB; PI3K/Akt/mTOR

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Aceglutamide.html

• Purity :

  98.0

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

• Smiles :

  O=C(N)CC[C@@H](C(O)=O)NC(C)=O

• Molecular Formula :

  C7H12N2O4

• Molecular Weight :

  188.18

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zhang J, et al. Enhanced thioredoxin, glutathione and Nrf2 antioxidant systems by safflower extract and aceglutamide attenuate cerebral ischaemia/reperfusion injury. J Cell Mol Med. 2020 May;24 (9) :4967-4980.|[2]Zhang R, et al. Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion. Restor Neurol Neurosci. 2015;33 (5) :741-59.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [2490-97-3]