2',6'-Dihydroxy-4'-methoxydihydrochalcone

• UNSPSC Description:

  2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro[1][2].

• Target Antigen:

  Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/2-6-dihydroxy-4-methoxydihydrochalcone.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C(O)C=C(OC)C=C1O)CCC2=CC=CC=C2

• Molecular Weight:

  272.30

• References & Citations:

  [1]Cerutti ML,et al. Effects of 2',6'-dihydroxy-4'-methoxydihidrochalcone on innate inflammatory response. Naunyn Schmiedebergs Arch Pharmacol. 2020 Nov;393(11):2061-2072. |[2]Bénédicte Portet, et al. Activity-guided isolation of antiplasmodial dihydrochalcones and flavanones from Piper hostmannianum var. berbicense. Phytochemistry. 2007 May;68(9):1312-20.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  35241-55-5