α-Galactosylceramide

CAT: 0804-HY-102022-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-102022-01Size:1 mg
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Description
α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. α-Galactosylceramide is a very potent NKT cell agonist and binds effectively to CD1d. The complex of α-Galactosylceramide plus CD1d binds the NKT cell TCR (T cell antigen receptor) [1][2][3][4].
CAS Number
[158021-47-7]
Product Name Alternative
α-GalCer; KRN7000
UNSPSC
12352005
Hazard Statement
H315, H319
Target
CD1; Interleukin Related; Transmembrane Glycoprotein
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/alpha-galactosylceramide.html
Purity
95.85
Solubility
DMSO : 0.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCCCCCCCCCCCCCCCCCCCCCCCCC(N[C@@H](CO[C@@H]1[C@@H]([C@H]([C@H]([C@@H](CO)O1)O)O)O)[C@H](O)[C@H](O)CCCCCCCCCCCCCC)=O
Molecular Formula
C50H99NO9
Molecular Weight
858.34
Precautions
H315, H319
References & Citations
[1]Godfrey DI, et al. Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest. 2004 Nov;114 (10) :1379-88.|[2]Morita M, et al. Practical Total Synthesis of (2S,3S,4R) -1-O- (α-D-Galactopyranosyl) -N-hexacosanoyl-2-amino-1,3,4-octadecanetriol, the Antitumorial and Immunostimulatory α-Galactosylcer-amide, KRN7000. Biosci Biotechnol Biochem. 1996 Jan;60 (2) :288-92.|[3]Kikuchi A, et al. In vitro anti-tumour activity of alpha-galactosylceramide-stimulated human invariant Valpha24+NKT cells against melanoma. Br J Cancer. 2001 Sep 1;85 (5) :741-6.|[4]Masahiro Morita, et al. Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice. J. Med. Chem. 1995, 38, 12, 2176-2187.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CD1d

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