N-Hydroxyphthalimide

• Description :

  N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473) . N-Hydroxyphthalimide has anticancer effects against breast and colon cancer[1][2][3].

• UNSPSC :

  12352200

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Akt; Apoptosis; Bcl-2 Family; Biochemical Assay Reagents; Caspase; mTOR; Survivin

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Apoptosis; Others; PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/n-hydroxyphthalimide.html

• Purity :

  99.89

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1C2=C(C(N1O)=O)C=CC=C2

• Molecular Formula :

  C8H5NO3

• Molecular Weight :

  163.13

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Wei W J, et al. Study on N‐hydroxyphthalimide as blocking agent for isocyanates. Journal of applied polymer science, 2002, 84 (7) : 1346-1352. |[2]Melone L, et al. N-Hydroxyphthalimide catalysts as bioactive pro-oxidants. RSC Advances, 2016, 6 (26) : 21749-21755. |[3]Wang M, et al. N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells. J Exp Clin Cancer Res. 2016 Mar 3;35:41.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported

• Isoform :

  Bcl-xL; Caspase 3; Caspase 9

• CAS Number :

  [524-38-9]