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N-Hydroxyphthalimide

CAT: 0804-HY-Y0396-01Size: 50 gDry Ice: NoHazardous: No
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CAT#:0804-HY-Y0396-01Size:50 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473) . N-Hydroxyphthalimide has anticancer effects against breast and colon cancer[1][2][3].
CAS Number
524-38-9
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Akt; Apoptosis; Bcl-2 Family; Biochemical Assay Reagents; Caspase; mTOR; Survivin
Type
Biochemical Assay Reagents
Related Pathways
Apoptosis; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-hydroxyphthalimide.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C(N1O)=O)C=CC=C2
Molecular Formula
C8H5NO3
Molecular Weight
163.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Wei W J, et al. Study on N‐hydroxyphthalimide as blocking agent for isocyanates. Journal of applied polymer science, 2002, 84 (7) : 1346-1352. |[2]Melone L, et al. N-Hydroxyphthalimide catalysts as bioactive pro-oxidants. RSC Advances, 2016, 6 (26) : 21749-21755. |[3]Wang M, et al. N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells. J Exp Clin Cancer Res. 2016 Mar 3;35:41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Isoform
Bcl-xL; Caspase 3; Caspase 9

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