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SR8278

CAT: 0804-HY-14415-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14415-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease[1][2][3].
CAS Number
1254944-66-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
REV-ERB
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sr8278.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CSC1=CC=C(C(N2C(C(OCC)=O)CC(C=CC=C3)=C3C2)=O)S1
Molecular Formula
C18H19NO3S2
Molecular Weight
361.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Kojetin , et al. Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem Biol. 2011 Feb 18;6 (2) :131-4.|[2]Dong D, et al. A validated ultra-performance liquid chromatography-tandem mass spectrometry method to identify the pharmacokinetics of SR8278 in normal and streptozotocin-induced diabetic rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 May 1;1020:142-7.|[3]Jeongah Kim, et al. Pharmacological Rescue with SR8278, a Circadian Nuclear Receptor REV-ERBα Antagonist as a Therapy for Mood Disorders in Parkinson's Disease. Neurotherapeutics. 2022 Mar;19 (2) :592-607.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
MBS5758700SR8278
A22100-25SR8278 25mg
A22100-100SR8278 100mg
A22100-5SR8278 5mg
A22100-1SR8278 1mg
A22100-50SR8278 50mg
A22100-10SR8278 10mg
A22100-10mM-DSR8278 10mM * 1mL in DMSO

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