Methyl cholate

• Description:

  Methyl cholate is a methyl ester of bile acid and sterol esters that can act as supramolecular carriers for aldoses (e.g., glucose, galactose, mannose) . Methyl cholate selectively binds to aldoses to form non-covalent complexes and migrates in supported liquid membranes (SLMs), thereby facilitating the transport of sugars. Cholic acid is one of the major bile acids produced by the liver and is synthesized from cholesterol. Methyl cholate can be used to study the selective separation and transport of carbohydrates[1][2][3].

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H320

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/methyl-cholate.html

• Concentration:

  10mM

• Purity:

  99.81

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@]([C@H](C)CCC(OC)=O)([H])CC3)([C@@H](O)C[C@]2([H])[C@]4(C)[C@](C[C@H](O)CC4)([H])C1)C

• Molecular Formula:

  C25H42O5

• Molecular Weight:

  422.60

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Al-Aboudi A, et al. Biotransformation of methyl cholate by Aspergillus niger. Steroids. 2009 Apr-May;74 (4-5) :483-6.|[2]L J Bennion, et al. Effects of Oral Contraceptives on the Gallbladder Bile of Normal Women. N Engl J Med, 294 (4), 189-92 1976 Jan 22|[3]Hassoune H, et al. Mechanism of transport of sugars across a supported liquid membrane using methyl cholate as mobile carrier[J]. Desalination, 2009, 242 (1-3) : 84-95.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [1448-36-8]