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Cystamine

CAT: 0804-HY-124476-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124476-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [1][2][3].
CAS Number
51-85-4
UNSPSC
12352211
Hazard Statement
H315, H318, H335
Target
Apoptosis; Caspase; Glutaminase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cystamine.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCSSCCN
Molecular Formula
C4H12N2S2
Molecular Weight
152.28
Precautions
H315, H318, H335
References & Citations
[1]Mathieu Lesort, et al. Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders. J Biol Chem. 2003 Feb 7;278 (6) :3825-30. |[2]Alpaslan Dedeoglu, et al. Therapeutic effects of cystamine in a murine model of Huntington's disease. J Neurosci. 2002 Oct 15;22 (20) :8942-50. |[3]Thomas M Jeitner, et al. Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo. Biosci Rep. 2018 Sep 5;38 (5) :BSR20180691.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3
Citation 01
ACS Environ Au. 2025 Aug 8.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Discov Oncol. 2025 May 30;16 (1) :952.|Small. 2025 Apr 17:e2501944.

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