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Aclimostat

CAT: 0804-HY-114196-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114196-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aclimostat (ZGN-1061) is a potent inhibitor of the MetAP2 enzyme and displays favorable efficacy and safety in preclinical studies. ZGN-1061 produced similar efficacy as beloranib for weight loss, improvements in metabolic parameters in a mouse model of obesity and insulin resistance, and concordant changes in gene transcription in HepG2 cells[1].
CAS Number
2082752-83-6
Product Name Alternative
ZGN-1061
UNSPSC
12352005
Target
MetAP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/aclimostat.html
Purity
98.0
Solubility
DMSO : 230 mg/mL (ultrasonic)
Smiles
C[C@]1([C@H](O1)C/C=C(C)\C)[C@]2([H])[C@]3(CC[C@H]([C@H]2OC)OC(N4CC(C4)CCN5CCOCC5)=O)CO3
Molecular Formula
C26H42N2O6
Molecular Weight
478.62
References & Citations
[1]Burkey BF, Hoglen NC, Inskeep P, Wyman M, Hughes TE, Vath JE. Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061. J Pharmacol Exp Ther. 2018 May;365 (2) :301-313.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
BA7974-1Aclimostat

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