Bafetinib

CAT: 0804-HY-50868-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-50868-01Size:5 mg
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Description
Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph+ leukemia cells. Bafetinib has antitumor activity[1][2][3].
CAS Number
[859212-16-1]
Product Name Alternative
INNO-406; NS-187
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis; Bcr-Abl; Src
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Bafetinib.html
Purity
99.18
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C(C(F)(F)F)=C1)CN2C[C@@H](N(C)C)CC2)NC3=CC=C(C)C(NC4=NC=CC(C5=CN=CN=C5)=N4)=C3
Molecular Formula
C30H31F3N8O
Molecular Weight
576.62
Precautions
H315, H319, H320
References & Citations
[1]Chen X, et al. Bafetinib Suppresses the Transcription of PD-L1 Through c-Myc in Lung Cancer. Front Pharmacol. 2022 Jun 2;13:897747.|[2]Grace MS, et al. The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo. Br J Pharmacol. 2014 Aug;171 (16) :3881-94.|[3]Kuroda J, et al. Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia. Cell Death Differ. 2007 Sep;14 (9) :1667-77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
GW4947-5mgBafetinib
A10119-5Bafetinib 5mg
A10119-10Bafetinib 10mg
A10119-50Bafetinib 50mg
A10119-100Bafetinib 100mg
MBS385810-01Bafetinib (INNO-406)

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