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Hippeastrine

CAT: 0804-HY-N6621-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6621-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
477-17-8
UNSPSC Description
Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC50 at 7.25?μg/mL. Antiproliferative and anticancer activities[1].
Target Antigen
Topoisomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hippeastrine.html
Solubility
10 mM in DMSO
Smiles
O=C1O[C@]([H])([C@H](C=C2CCN(C32)C)O)[C@@]3([H])C4=CC5=C(OCO5)C=C14
Molecular Weight
315.32
References & Citations
[1]Chen GL, et al. Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I. Sci Rep. 2016;6:38284. Published 2016 Dec 6.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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