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ML786

CAT: 0804-HY-14979Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14979Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML786 is a potent and orally bioavailable Raf inhibitor, with IC50s of 2.1, 4.2, and 2.5 nM for V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC50=[1].
CAS Number
1237586-97-8
UNSPSC
12352005
Target
Bcr-Abl; Discoidin Domain Receptor; Ephrin Receptor; Raf; RET; VEGFR
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Assay Protocol
https://www.medchemexpress.com/ml786.html
Smiles
O=C(CC1)NC2=C1C(OC3=CC=C(CC[C@@H](NC(C4=CC(C(F)(F)F)=CC(C(C)(C)N)=C4)=O)C5)C5=C3)=CC=N2
Molecular Formula
C29H29F3N4O3
Molecular Weight
538.56
References & Citations
[1]Gould AE, et, al. Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors. J Med Chem. 2011 Mar 24;54 (6) :1836-46.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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