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KU004

CAT: 0804-HY-164489Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164489Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KU004 is a potent dual EGFR/HER2 inhibitor with anticancer effects. KU004 inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR and downstream Akt and Erk pathways and induces cell Apoptosis mainly via the extrinsic pathway. KU004 is a quinazoline derivative[1][2].
CAS Number
1260401-93-1
UNSPSC
12352005
Target
Akt; Apoptosis; EGFR; ERK
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ku004.html
Smiles
ClC1=C(OCC2=CC(F)=CC=C2)C=CC(NC3=NC=NC4=CC=C(C#CCN5CCP(CC5)(C)=O)C=C43)=C1
Molecular Formula
C29H27ClFN4O2P
Molecular Weight
548.98
References & Citations
[1]Tian C, et al. A novel dual EGFR/HER2 inhibitor KU004 induces cell cycle arrest and apoptosis in HER2-overexpressing cancer cells. Apoptosis. 2015 Dec;20 (12) :1599-612.|[2]Tian C, et al. Inhibition of glycolysis by a novel EGFR/HER2 inhibitor KU004 suppresses the growth of HER2+ cancer. Exp Cell Res. 2017 Aug 15;357 (2) :211-221.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19237474-01KU004

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