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TBB

CAT: 0804-HY-14394-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14394-04Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TBB is a cell-permeable and ATP-competitive CK2 inhibitor with an IC50 of 0.15 μM for rat liver CK2.
CAS Number
17374-26-4
Product Name Alternative
NSC 231634; Casein Kinase II Inhibitor I
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Casein Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TBB.html
Concentration
10mM
Purity
98.54
Solubility
DMSO : ≥ 100 mg/mL
Smiles
BrC1=C2C(NN=N2)=C(Br)C(Br)=C1Br
Molecular Formula
C6HBr4N3
Molecular Weight
434.71
Precautions
H302, H315, H319, H335
References & Citations
[1]De Moliner E, et al. Alternative binding modes of an inhibitor to two different kinases. Eur J Biochem. 2003 Aug;270 (15) :3174-81.|[2]Orzechowska E, et al. Time schedule-dependent effect of the CK2 inhibitor TBB on PC-3 human prostate cancer cell viability. Oncol Rep. 2012 Jan;27 (1) :281-5.|[3]Sarno S, et al. Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2') . FEBS Lett. 2001 May 4;496 (1) :44-8.|[4]Ljubimov AV, et al. Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization. Invest Ophthalmol Vis Sci. 2004 Dec;45 (12) :4583-91.|[5]Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415 (3) :353-65.|[6]Chen Z, et al. CK2α promotes advanced glycation end products-induced expressions of fibronectin and intercellular adhesion molecule-1 via activating MRTF-A in glomerular mesangial cells. Biochem Pharmacol. 2017 Dec 6;148:41-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK2

Chemical Information

4,5,6,7-Tetrabromobenzotriazole

a CK2 kinase inhibitor

CAS Number17374-26-4
PubChem CID1694
IUPAC Name4,5,6,7-tetrabromo-2H-benzotriazole
Molecular FormulaC6HBr4N3
Molecular Weight434.71
XLogP3.8
Topological Polar Surface Area41.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Heavy Atom Count13
Formal Charge0
Complexity184
SMILES
C1(=C(C2=NNN=C2C(=C1Br)Br)Br)Br
InChI
InChI=1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
InChIKey
OMZYUVOATZSGJY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4,5,6,7-Tetrabromobenzotriazole
CAS: 17374-26-4
CID: 1694
Formula: C6HBr4N3
MW: 434.71
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight434.71
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass434.68630
Monoisotopic Mass430.69040
Topological Polar Surface Area41.6 Ų
Heavy Atom Count13
Formal Charge0
Complexity184
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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