E0924G

CAT: 0804-HY-168336-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-168336-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

E0924G is an orally active activator for PPARδ with EC50 of 2.82 μM. E0924G promotes the upregulation of osteoprotegerin (OPG) with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibites F-actin ring formation in RAW264.7 macrophages. E0924G regulates the bone density and bone loss in ovariectomized (OVX) and age-related osteoporosis models[1].

CAS Number

2909474-29-7

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/e0924g.html

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C)O1)NC2=NC=CC(OC)=C2

Molecular Formula

C12H12N2O3

Molecular Weight

232.24

References & Citations

[1]Li Y, et al., The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice. Bioorg Chem. 2024 Jun;147:107364.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PPARβ/δ

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GTR19241091-01	E0924G

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