Products for Research Use Only
RegisterLogin

ZM 253270

CAT: 0804-HY-117053Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-117053Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ZM 253270 is a species-selective non-peptide NK-2 receptor (NK-2R) antagonist. ZM 253270 competitively inhibits the binding of [3H]NKA to native or cloned NK-2R from hamster bladder (Ki=2 nM), but has a weaker inhibitory effect (48-fold) on the binding of [3H]NKA to cloned human NK-2R[1].
CAS Number
169340-04-9
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zm-253270.html
Smiles
O=C(N1CCN(CC1)C2=NC(C(N(C(C)C)C3)=O)=C3C(NC4=CC=C(C=C4)Cl)=N2)/C(C)=N/O
Molecular Formula
C22H26ClN7O3
Molecular Weight
471.94
References & Citations
[1]Aharony D, et al. Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 274 (3) : 1216-1221.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK2R

Chemical Information

ZM 253270

a pyrrolopyrimidine; structure given in first source

CAS Number169340-04-9
PubChem CID9847605
IUPAC Name4-(4-chloroanilino)-2-[4-[(2E)-2-hydroxyiminopropanoyl]piperazin-1-yl]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
Molecular FormulaC22H26ClN7O3
Molecular Weight471.9
XLogP3.3
Topological Polar Surface Area114
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count33
Formal Charge0
Complexity750
SMILES
CC(C)N1CC2=C(C1=O)N=C(N=C2NC3=CC=C(C=C3)Cl)N4CCN(CC4)C(=O)/C(=N/O)/C
InChI
InChI=1S/C22H26ClN7O3/c1-13(2)30-12-17-18(21(30)32)25-22(26-19(17)24-16-6-4-15(23)5-7-16)29-10-8-28(9-11-29)20(31)14(3)27-33/h4-7,13,33H,8-12H2,1-3H3,(H,24,25,26)/b27-14+
InChIKey
OYOSXTKSOATNNB-MZJWZYIUSA-N
Chemical Structure
2D Structure
2D structure of ZM 253270
CAS: 169340-04-9
CID: 9847605
Formula: C22H26ClN7O3
MW: 471.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight471.9
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass471.1785654
Monoisotopic Mass471.1785654
Topological Polar Surface Area114 Ų
Heavy Atom Count33
Formal Charge0
Complexity750
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-P991309-01ZM-008
HY-13785-01ZM 306416
HY-13450-01ZM 449829
HY-163760ZM-32
HY-10128-01ZM-447439
HY-13343-01ZM 336372
HY-110045ZM-306416 (hydrochloride)
HY-13785R-01ZM 306416 (Standard)
HY-159069-01Zymosan (ZM), 95%
HY-10128RZM-447439 (Standard)

Alternative Products

CatalogName
MBS5778892ZM 253270

Popular Products