Coluracetam

CAT: 0804-HY-17553-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-17553-01Size:5 mg

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Description

Coluracetam (MKC-231) is an orally taken choline uptake enhancer. Coluracetam can improve the reduced acetylcholine levels in the hippocampus of rats and mice, enhancing learning difficulties, memory deficits, and cognitive impairments. Coluracetam induces a lower degree of hepatic venous hyperglycemia[1][2][3].

CAS Number

135463-81-9

Product Name Alternative

MKC-231

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Coluracetam.html

Purity

99.87

Solubility

DMSO : ≥ 20 mg/mL|H2O : 0.4 mg/mL (ultrasonic; warming)

Smiles

O=C(NC1=C2C(OC(C)=C2C)=NC3=C1CCCC3)CN4C(CCC4)=O

Molecular Formula

C19H23N3O3

Molecular Weight

341.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Murai S, et al. MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. J Neural Transm Gen Sect. 1994;98 (1) :1-13.|[2]Tomoko Bessho, et al. MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats. J Neural Transm (Vienna) . 2008 Jul;115 (7) :1019-25.|[3]K Uemura, et al. Central nervous system-mediated hyperglycemic effects of NIK-247, a cholinesterase inhibitor, and MKC-231, a choline uptake enhancer, in rats. Jpn J Pharmacol. 1999 Jan;79 (1) :113-5.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Alternative Products

Catalog	Name
sc-482365	Coluracetam
A13516-25	Coluracetam 25mg
A13516-500	Coluracetam 500mg
A13516-5	Coluracetam 5mg
A13516-50	Coluracetam 50mg
A13516-10	Coluracetam 10mg
A13516-1000	Coluracetam 1g
A13516-100	Coluracetam 100mg

Coluracetam

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