1-(Isothiazol-3-yl)ethan-1-one

1-(Isothiazol-3-yl)ethan-1-one

• CAS Number: 88511-35-7
• UNSPSC Description: 1-(Isothiazol-3-yl)ethan-1-one (Q11) is a CYP2E1 inhibitor. 1-(Isothiazol-3-yl)ethan-1-one can be used in rheumatoid arthritis and sepsis related research[1].
• Target Antigen: Cytochrome P450
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/1-isothiazol-3-yl-ethan-1-one.html
• Purity: 95.0
• Smiles: CC(C1=NSC=C1)=O
• Molecular Weight: 127.16
• References & Citations: [1]Han Z,et al. Discovery of CYP2E1 as a novel target in rheumatoid arthritis and validation by a new specific CYP2E1 inhibitor. Biochem Pharmacol. 2024 Aug 20;229:116501. |[2]Han Z,et al. Discovery of CYP2E1 as a novel target in rheumatoid arthritis and validation by a new specific CYP2E1 inhibitor. Biochem Pharmacol. 2024 Aug 20;229:116501. |[3]Gao N, et al. The CYP2E1 inhibitor Q11 ameliorates LPS-induced sepsis in mice by suppressing oxidative stress and NLRP3 activation. Biochem Pharmacol. 2023 Aug;214:115638.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported