Loratadine (Standard)

Loratadine (Standard) is the analytical standard of Loratadine. This product is intended for research and analytical applications. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

79794-75-5

Loratidine (Standard) ; SCH 29851 (Standard)

12352005

H410

Dengue Virus; Flavivirus; Histamine Receptor; Reference Standards

Reference Standards

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Infection; Endocrinology; Inflammation/Immunology; Cancer

https://www.medchemexpress.com/loratadine-standard.html

99.87

O=C(N1CC/C(CC1)=C2C3=CC=C(Cl)C=C3CCC4=CC=CN=C4\2)OCC

C22H23ClN2O2

382.88

H410

[1]Kay GG, Harris AG. Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clin Exp Allergy. 1999 Jul;29 Suppl 3:147-50.|[2]Menardo JL, Horak F, Danzig MR, Czarlewski W. A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19 (6) :1278-93; discussion 1523-4.|[3]Monroe EW. Loratadine in the treatment of urticaria. Clin Ther. 1997 Mar-Apr;19 (2) :232-42.|[4]Haria M, Fitton A, Peters DH. Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders. Drugs. 1994 Oct;48 (4) :617-37.|[5]Roman IJ, Danzig MR. Loratadine. A review of recent findings in pharmacology, pharmacokinetics, efficacy, and safety, with a look at its use in combination with pseudoephedrine. Clin Rev Allergy. 1993 Spring;11 (1) :89-110.|[6]Shahen M, et al. Dengue virus causes changes of MicroRNA-genes regulatory network revealing potential targets for antiviral drugs. BMC Syst Biol. 2018 Jan 4;12 (1) :2.|[7]Kleine-Tebbe J, et al. Inhibition of IgE- and non-IgE-mediated histamine release from human basophil leukocytes in vitro by a histamine H1-antagonist, desethoxycarbonyl-loratadine. J Allergy Clin Immunol. 1994;93 (2) :494-500.

Blue Ice

-20°C, sealed storage, away from light and moisture