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Fenclonine

CAT: 0804-HY-B1368-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1368-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research[1][2][3].
CAS Number
7424-00-2
Product Name Alternative
4-Chloro-DL-phenylalanine; PCPA; CP-10188
UNSPSC
12352005
Hazard Statement
H301, H317
Target
Tryptophan Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-Chloro-DL-phenylalanine.html
Purity
99.92
Solubility
1 M NaOH : 150 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic; adjust pH to 2 with HCl) |H2O : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC(CC1=CC=C(Cl)C=C1)C(O)=O
Molecular Formula
C9H10ClNO2
Molecular Weight
199.64
Precautions
H301, H317
References & Citations
[1]M Jouvet. Sleep and serotonin: an unfinished story. Neuropsychopharmacology. 1999 Aug;21 (2 Suppl) :24S-27S.|[2]A K Sanyal, et al. Prostaglandins: antinociceptive effect of prostaglandin E1 in the rat. Clin Exp Pharmacol Physiol. 1977 May-Jun;4 (3) :247-55.|[3]Shyamshree S S Manna, et al. Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine. Behav Pharmacol. 2015 Apr;26 (3) :268-81.|[4]Zheng Y, et al. In silico Analysis and Experimental Validation of Lignan Extracts from Kadsura longipedunculata for Potential 5-HT1AR Agonists. PLoS One. 2015 Jun 15;10 (6) :e0130055.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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