Colistimethate

CAT: 0804-HY-P4067Size: InquireDry Ice: NoHazardous: No
CAT#:0804-HY-P4067Size:Inquire
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CAS Number
[12705-41-8]
UNSPSC Description
Colistimethate is a polymyxin with cytotoxicity to renal tubular cells. Colistimethate has poorly inactive in vivo. Colistimethate shows seldomly detectable activity against 6 strains of P. aeruginosa[1][2].
Target Antigen
Others
Type
Peptides
Related Pathways
Others
Field of Research
Others; Cancer
Assay Protocol
https://www.medchemexpress.com/colistimethate.html
Solubility
10 mM in DMSO
Smiles
CCC(C)CCCCC(NC(CCNCS(=O)(O[Na])=O)C(NC(C(C)O)C(NC(CCNCS(=O)(O[Na])=O)C(NC1CCNC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC1=O)CCNCS(=O)(O[Na])=O)=O)CC(C)C)=O)CC(C)C)=O)CCNCS(=O)(O[Na])=O)=O)CCNCS(=O)(O[Na])=O)=O)C(C)O)=O)=O)=O)=O)=O
Molecular Weight
1749.82
References & Citations
[1]Zavascki AP, et al. Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B? Antimicrob Agents Chemother. 2017 Feb 23;61(3):e02319-16. |[2]Davis SD. Activity of gentamicin, tobramycin, polymyxin B, and colistimethate in mouse protection tests with Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1975 Jul;8(1):50-3.
Shipping Conditions
Room temperature
Clinical Information
Launched

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