Colistimethate

• UNSPSC Description:

  Colistimethate is a polymyxin with cytotoxicity to renal tubular cells. Colistimethate has poorly inactive in vivo. Colistimethate shows seldomly detectable activity against 6 strains of P. aeruginosa[1][2].

• Target Antigen:

  Others

• Type:

  Peptides

• Related Pathways:

  Others

• Field of Research:

  Others; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/colistimethate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCC(C)CCCCC(NC(CCNCS(=O)(O[Na])=O)C(NC(C(C)O)C(NC(CCNCS(=O)(O[Na])=O)C(NC1CCNC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC1=O)CCNCS(=O)(O[Na])=O)=O)CC(C)C)=O)CC(C)C)=O)CCNCS(=O)(O[Na])=O)=O)CCNCS(=O)(O[Na])=O)=O)C(C)O)=O)=O)=O)=O)=O

• Molecular Weight:

  1749.82

• References & Citations:

  [1]Zavascki AP, et al. Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B? Antimicrob Agents Chemother. 2017 Feb 23;61(3):e02319-16. |[2]Davis SD. Activity of gentamicin, tobramycin, polymyxin B, and colistimethate in mouse protection tests with Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1975 Jul;8(1):50-3.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  [12705-41-8]