Cofrogliptin

CAT: 0804-HY-147257-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-147257-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Cofrogliptin (HSK7653) (compound 2), a tetrahydropyran derivative, is a potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor with Long-acting antidiabetic efficacy. Cofrogliptin (compound 2) has a great potential for type 2 diabetes mellitus (T2DM) [1].

CAS Number

1844874-26-5

Product Name Alternative

HSK7653

UNSPSC

12352005

Target

Dipeptidyl Peptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cofrogliptin.html

Purity

99.29

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(F)([C@@H](O[C@]1([H])C(C=C2F)=C(C=C2)F)[C@@](N(CC3=N4)CC3=CN4[S](C)(=O)=O)([H])C[C@@H]1N)F

Molecular Formula

C18H19F5N4O3S

Molecular Weight

466.43

References & Citations

[1]International Nonproprietary Names for Pharmaceutical Substances (INN) |[2]Chen Zhang, et al. Design, Synthesis, and Evaluation of a Series of Novel Super Long-Acting DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. J Med Chem. 2020 Jul 9;63 (13) :7108-7126.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

DPP-4

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