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Lonigutamab

CAT: 0804-HY-P99712-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99712-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lonigutamab (hz208F2-4) is a humanized anti-IGF-1R monoclonal antibody, serveing as a targeting vector for antibody-drug conjugates (ADCs) . Lonigutamab causes G2-M phase cell cycle arrest and increases apoptosis in IGF-1R-overexpressing tumor cells. Lonigutamab demonstrates potent antitumor efficacy in IGF-1R-overexpressing xenograft models. Lonigutamab can be used for the study of Solid tumors with overexpression of IGF-1R and thyroid eye diseases[1][2].
CAS Number
2362015-67-4
Product Name Alternative
Hz208F2-4
UNSPSC
12352203
Target
ADC Antibody; Apoptosis; IGF-1R
Type
Inhibitory Antibodies
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lonigutamab.html
Purity
95.00
Solubility
H2O
Smiles
[Lonigutamab]
Molecular Weight
(145.12 kDa)
References & Citations
[1]Akla B, et al. Efficacy of the Antibody-Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors. Mol Cancer Ther. 2020 Jan;19 (1) :168-177.|[2]Pimenta EM, et al. Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity. bioRxiv [Preprint]. 2025 Jan 24:2025.01.20.633920.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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