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Elsibucol

CAT: 0804-HY-14921-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14921-01Size:1 mg
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Description
Elsibucol is a VCAM1 inhibitor for the study of organ transplant rejection. Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. Elsibucol lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries, thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury[1][2][3].
CAS Number
216167-95-2
UNSPSC
12352005
Target
Integrin; Transmembrane Glycoprotein
Type
Reference compound
Related Pathways
Cytoskeleton; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/elsibucol.html
Purity
99.35
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(CCCOC1=C(C(C)(C)C)C=C(SC(C)(C)SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)C=C1C(C)(C)C)O
Molecular Formula
C35H54O4S2
Molecular Weight
602.93
References & Citations
[1]Dussault S, et al. Elsibucol inhibits atherosclerosis following arterial injury: multifunctional effects on cholesterol levels, oxidative stress and inflammation[J]. Atherosclerosis, 2014, 237 (1) : 194-199.|[2]Murata S, et al. Effects of AGI-1096, a novel antioxidant compound with anti-inflammatory and antiproliferative properties, on rodent allograft arteriosclerosis[J]. Transplantation, 2004, 77 (10) : 1494-1500.|[3]First M R, et al. New drugs to improve transplant outcomes[J]. Transplantation, 2004, 77 (9) : S88-S92.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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