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Lucidone

CAT: 0804-HY-N3364Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N3364Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM) [1][2].
CAS Number
19956-53-7
UNSPSC
12352005
Hazard Statement
H315-H319
Target
COX; Dengue Virus; Flavivirus; IKK; JNK; NF-κB; NO Synthase; p38 MAPK; TNF Receptor
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lucidone.html
Solubility
10 mM in DMSO
Smiles
OC(/C=C/C1=CC=CC=C1)=C2C(C(OC)=CC\2=O)=O
Molecular Formula
C15H12O4
Molecular Weight
256.25
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Senthil Kumar KJ, et aL. Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways. Planta Med. 2009 Apr;75 (5) :494-500. |[2]Chen WC, et al. Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1. Virulence. 2018 Jan 1;9 (1) :588-603.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; IKK; iNOS; JNK; NF-κB; NF-κB1/p50; p38 MAPK; RelA/p65

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