Methyl pyropheophorbide-a

• Description :

  Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth[1][2].

• Product Name Alternative :

  Pyropheophorbide-a methyl ester

• UNSPSC :

  12352005

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/methyl-pyropheophorbide-a.html

• Purity :

  99.14

• Solubility :

  DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CC1=C(N2)/C=C(C(CC)=C3C)\N=C3/C=C(C(C=C)=C/4C)\NC4=C/C5=N/C([C@H]([C@@H]5C)CCC(OC)=O)=C(C6)\C2=C1C6=O

• Molecular Formula :

  C34H36N4O3

• Molecular Weight :

  548.67

• References & Citations :

  [1]Sun X, et, al. Photodynamic therapy with pyropheophorbide-a methyl ester in human lung carcinoma cancer cell: efficacy, localization and apoptosis. Photochem Photobiol. 2002 Jun;75 (6) :644-51.|[2]Tian Y, et, al. Cell death induced by MPPa-PDT in prostate carcinoma in vitro and in vivo. Biochem Biophys Res Commun. 2006 Sep 22;348 (2) :413-20.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [6453-67-4]