Products for Research Use Only
RegisterLogin

Dihydrochelerythrine

CAT: 0804-HY-N0903-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N0903-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Dihydrochelerythrine is a natural compound isolated from Corydalis yanhusuo; has antifungal activity. IC50 value: Target: in vitro: Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 μg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner [1]. Dihydrochelerythrine appeared to be less cytotoxic since the viability of cells exposed to 20 microM dihydrochelerythrine for 24h was reduced only to 53%. A dose-dependent induction of apoptosis and necrosis by chelerythrine and dihydrochelerythrine was confirmed by annexin V/propidium iodide dual staining flow cytometry [2]. Dihydrochelerythrine (4) exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively [3].
CAS Number
6880-91-7
Product Name Alternative
12,13-Dihydrochelerythrine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fungal
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Dihydrochelerythrine.html
Concentration
10mM
Purity
99.39
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
CN1C(C2=CC(OCO3)=C3C=C2C=C4)=C4C5=CC=C(OC)C(OC)=C5C1
Molecular Formula
C21H19NO4
Molecular Weight
349.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Feng G, et al. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25 (11) :1082-9.|[2]Vrba J, et al. Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells. Toxicol In Vitro. 2008 Jun;22 (4) :1008-17.|[3]Tantapakul C, et al. Antibacterial compounds from Zanthoxylum rhetsa. Arch Pharm Res. 2012 Jul;35 (7) :1139-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-N8089Bis (dihydrochelerythrinyl) amine

Alternative Products

CatalogName
AB2031Dihydrochelerythrine
GTR19279968-016-n-Propoxy dihydrochelerythrine
T83281-016- (1-Hydroxyethyl) -5,6-dihydrochelerythrine
MBS58249306-(1-Hydroxyethyl)-5,6-dihydrochelerythrine

Popular Products