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RA839

CAT: 0804-HY-110275-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110275-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RA839 is a selective Nrf2/ARE pathway agonist and non-covalent small molecule binder of Keap1 (Kd is approximately 6 μM) . RA839 prevents inducible nitric oxide synthase expression and nitric oxide release. RA839 exerts anti-rotaviral and anti-inflammatory effects[1][2].
CAS Number
1832713-02-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Keap1-Nrf2; NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ra839.html
Purity
98.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1CN(C2=C3C=CC=CC3=C(NS(=O)(C4=C(C)C(C)=CC(C)=C4C)=O)C=C2)CC1)O
Molecular Formula
C25H28N2O4S
Molecular Weight
452.57
Precautions
H302, H315, H319
References & Citations
[1]Winkel AF, et al. Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling. J Biol Chem. 2015;290 (47) :28446-28455.|[2]Patra U, et al. RA-839, a selective agonist of Nrf2/ARE pathway, exerts potent anti-rotaviral efficacy in vitro. Antiviral Res. 2019 Jan;161:53-62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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