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Bavdegalutamide

CAT: 0804-HY-138641-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138641-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bavdegalutamide (ARV-110) is an orally active, specific androgen receptor (AR) PROTAC degrader. Bavdegalutamide promotes ubiquitination and degradation of AR. Bavdegalutamide can be used for the research of prostate cancer (Pink: AR ligand ; Blue: E3 ligase ligand (HY-W093272) ; Black: linker (HY-W091986) ).
CAS Number
2222112-77-6
Product Name Alternative
ARV-110
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Androgen Receptor; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arv-110.html
Purity
99.64
Solubility
DMSO : 26.67 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 80°C)
Smiles
O=C(C1=NN=C(N2CCC(CN3CCN(C4=CC5=C(C(N(C(CC6)C(NC6=O)=O)C5=O)=O)C=C4F)CC3)CC2)C=C1)N[C@H]7CC[C@H](OC8=CC=C(C#N)C(Cl)=C8)CC7
Molecular Formula
C41H43ClFN9O6
Molecular Weight
812.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Taavi Neklesa, et al. ARV-110: An androgen receptor PROTAC degrader for prostate cancer. American Association for Cancer Research. 2018. 78 (13) : pp. 5236.|[2]Taavi K Neklesa, et al. ARV-110: an oral androgen receptor PROTAC degrader for prostate cancer. GU ASCO 2019
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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