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Iclepertin

CAT: 0804-HY-138935-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138935-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Iclepertin (BI-425809) is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. Iclepertin is inactive against GlyT2. Iclepertin can be used for Alzheimer disease and schizophrenia research[1].
CAS Number
1421936-85-7
Product Name Alternative
BI-425809
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GlyT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bi-425809.html
Purity
99.97
Solubility
DMSO : 11.36 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(C=CC(S(C)(=O)=O)=C1)O[C@H](C)C(F)(F)F)N2C[C@]3(C4=NOC(C(F)(F)F)=C4)[C@@](C2)([H])C3
Molecular Formula
C20H18F6N2O5S
Molecular Weight
512.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Holger Rosenbrock, et al. Evaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies. Clin Transl Sci. 2018 Nov;11 (6) :616-623.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
GlyT1

Alternative Products

CatalogName
GTR19190893-01Iclepertin

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