Ecliptasaponin A

• Description :

  Ecliptasaponin A is an orally active pentacyclic triterpenoid saponin. Ecliptasaponin A exerts anti-tumor activity by activating ASK1/JNK pathway, inducing apoptosis and autophagy in lung cancer cells. Ecliptasaponin A exerts anti-inflammatory/anti-fibrotic effects and protects the cardiovascular system by inhibiting the HMGB1/TLR4/NF-κB pathway, and the expression of COX-2 and MMP-9. Ecliptasaponin A can enhance SOD activity, reduce MDA levels, and alleviate oxidative stress damage. Ecliptasaponin A exerts chondroprotective effects by inhibiting the expression of MMP13 and regulating inflammatory factors. Ecliptasaponin A improves ovarian function and regulates sex hormones by upregulating the expression of ESR1 receptors[1][2][3][4][5][6][7].

• UNSPSC :

  12352005

• Target :

  Apoptosis; ASK1; Autophagy; COX; JNK; MMP; NF-κB; SOD; TNF Receptor; Toll-like Receptor (TLR)

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Endocrinology; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ecliptasaponin-a.html

• Purity :

  99.50

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1(C)[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)CC[C@]3(C)[C@@]4([H])CC=C5[C@]6([H])CC(C)(C)CC[C@@](C(O)=O)6[C@H](O)C[C@](C)5[C@@](C)4CC[C@@]13[H]

• Molecular Formula :

  C36H58O9

• Molecular Weight :

  634.84

• References & Citations :

  Eclipta prostrata

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  COX-2; MMP-13; MMP-2; MMP-9; NF-κB; TLR4

• CAS Number :

  [78285-90-2]