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Anserine-d4

CAT: 0804-HY-113354SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113354SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anserine-d4 is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD) -model mice[1][2].
CAS Number
1201658-81-2
Product Name Alternative
SR-202
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Purity
99.38
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@H](CC1=CN=CN1C)NC(C([2H])([2H])C([2H])([2H])N)=O
Molecular Formula
C10H12D4N4O3
Molecular Weight
244.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Jun Kaneko, et al. Anserine (beta-alanyl-3-methyl-L-histidine) improves neurovascular-unit dysfunction and spatial memory in aged AβPPswe/PSEN1dE9 Alzheimer's-model mice. Sci Rep. 2017 Oct 3;7 (1) :12571.|[3]Boldyrev AA, et al. The histidine-containing dipeptides, carnosine and anserine: distribution, properties and biological significance. Adv Enzyme Regul. 1990;30:175-94.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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