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TT01001

CAT: 0804-HY-114520-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114520-01Size:5 mg
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Description
TT01001 is a selective and orally active mitoNEET agonist and a monoamine oxidase B (MAO-B) inhibitor (IC50 = 8.84 μM) . TT01001 does not activate PPARγ but interacts with MitoNEET. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction. TT01001 improves type II diabetes and ameliorates mitochondrial function of mice. TT01001 can used for the studies of type II diabetes and neurological disorders [1][2][3].
CAS Number
1022367-69-6
Product Name Alternative
NSC144303
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Mitochondrial Metabolism; Monoamine Oxidase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tt01001.html
Purity
99.38
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(OCC)N1CCC(CC1)NC(NC2=CC(Cl)=CC(Cl)=C2)=S
Molecular Formula
C15H19Cl2N3O2S
Molecular Weight
376.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Takehiro Takahashi, et al. A novel MitoNEET ligand, TT01001, improves diabetes and ameliorates mitochondrial function in db/db mice. J Pharmacol Exp Ther. 2015, 352, 2.|[2]Shi G, et al. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction after subarachnoid hemorrhage in rats. Neuroreport. 2020;31 (11) :845-850. |[3]Barbosa Belchior M, et al. Synthesis and evaluation of enzyme inhibition by novel TT01001 derivatives as monoamine oxidase B inhibitors. Bioorg Med Chem Lett. 2025 Mar 1;117:130045.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAO-B

Alternative Products

CatalogName
BA3213-10TT01001

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