Sesamolin

• Description :

  Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesamolin inhibits lipid peroxidation and shows neuroprotection effect. Sesamolinl potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression. Sesamolin is orally active[1][2][3][4].

• UNSPSC :

  12352005

• Hazard Statement :

  H317

• Target :

  Caspase; JNK; NF-κB; p38 MAPK; Reactive Oxygen Species (ROS)

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/sesamolin.html

• Concentration :

  10mM

• Purity :

  99.78

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  [H][C@@]12[C@@](CO[C@@H]2C3=CC(OCO4)=C4C=C3)([H])[C@H](OC1)OC5=CC(OCO6)=C6C=C5

• Molecular Formula :

  C20H18O7

• Molecular Weight :

  370.35

• Precautions :

  H317

• References & Citations :

  [1]Dorothea Bedigian, et al. Sesamin, sesamolin and the origin of sesame. Biochemical Systematics and Ecology. Volume 13, Issue 2, 23 May 1985, Pages 133-139.|[2]Myung-Hwa Kang, et al. Sesamolin Inhibits Lipid Peroxidation in Rat Liver and Kidney. The Journal of Nutrition, Volume 128, Issue 6, June 1998, Pages 1018–1022.|[3]Rolis Chien‐Wei Hou, et al. Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells.|[4]Lim JS, et al. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. Br J Nutr. 2007 Jan;97 (1) :85-95.|[5]Yang X, et al., Sesamolin Protects Mice From Ovariectomized Bone Loss by Inhibiting Osteoclastogenesis and RANKL-Mediated NF-κB and MAPK Signaling Pathways. Front Pharmacol. 2021 Jun 14;12:664697.|[6]Yu J, et al., Sesamolin Alleviates Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites in High-Fat and High-Fructose Diet-Fed Mice. Int J Mol Sci. 2022 Nov 10;23 (22) :13853.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [526-07-8]