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Thalidomide-O-C6-NHBoc

CAT: 0804-HY-141887-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-141887-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
CAS Number
2509093-23-4
UNSPSC
12352005
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-o-c6-nhboc.html
Purity
95.99
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(OC(C)(C)C)NCCCCCCOC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
Molecular Formula
C24H31N3O7
Molecular Weight
473.52
References & Citations
[1]Daniel A. HARKI, et al. Compounds that degrade kinases and uses thereof. WO2020247537A1.|[2]Zhang NN, et al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020;182 (5) :1271-1283.e16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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