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Seribantumab

CAT: 0804-HY-P99268-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99268-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models[1].
CAS Number
1334296-12-6
Product Name Alternative
SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant Antibody
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; EGFR
Type
Inhibitory Antibodies
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/seribantumab.html
Purity
96.043
Solubility
10 mM in DMSO
Smiles
[Seribantumab]
Molecular Weight
(143.14 kDa)
Precautions
H302, H315, H319, H335
References & Citations
[1]Odintsov I, et al. The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions. Clin Cancer Res. 2021 Jun 1;27 (11) :3154-3166.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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