Adenosine-13C5

Adenosine-13C5

• CAS Number: 159496-13-6
• UNSPSC Description: Adenosine-13C5 is the 13C labeled Adenosine[1]. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[2][3].
• Target Antigen: Apoptosis; Autophagy; Endogenous Metabolite; Nucleoside Antimetabolite/Analog
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/adenosine-13c5.html
• Purity: 99.35
• Solubility: 10 mM in DMSO
• Smiles: NC1=C(N=CN2[13C@H]3[13C@H](O)[13C@H](O)[13C@@H]([13CH2]O)O3)C2=NC=N1
• Molecular Weight: 272.20
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625.|[3]Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 200714(7):1315-1323.|[4]Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 201941(2):829-838.|[5]Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009111(4):904-915.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported